By

Alan Anderson

10
Feb
2025

Rethinking Risk-Benefit in Sickle Cell Disease Therapy

Pfizer’s decision last fall to withdraw voxelotor (Oxbryta) from the worldwide market is an example of how companies make risk-benefit calculations about medicines, and how those decisions vary widely from one category to another. Cancer drugs have their own set of standards. The risk-benefit calculus routinely accommodates uncertainty and severe side effects, if the medicine offers a modest and temporary...
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