By

Luke Timmerman

1
Feb
2022

Targeting Integrins With Small Molecules: Praveen Tipirneni on The Long Run

Today’s guest on The Long Run is Praveen Tipirneni. Praveen is the CEO of Waltham, Mass.-based Morphic Therapeutic. Morphic Therapeutic is developing oral small molecule drugs aimed at integrin targets. There’s some fascinating biology and computational technology underpinning this work, which I discussed a couple years ago on The Long Run with Morphic scientific founder Tim Springer. Just to review...
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27
Jan
2022

A Small Step on Drug Pricing

Mark Cuban, the billionaire-turned-reality TV star, made news this week with the Mark Cuban Cost Plus Drug Company. Cuban has been saying for a while that he wants to stick it to the man. The biopharma man. “I could make a fortune from this,” Cuban told Texas Monthly in September. “But I won’t. I’ve got enough money. I’d rather f—...
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20
Jan
2022

Reflecting on MLK and Science in Society

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13
Jan
2022

The Biogen Debacle Continues

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9
Dec
2021

A Missed Opportunity for Grownups

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6
Dec
2021

Targeted Small Molecule Protein Degraders: Nello Mainolfi on The Long Run

Today’s guest on The Long Run is Nello Mainolfi. Nello is the president and CEO of Cambridge, Mass.-based Kymera Therapeutics. Kymera is working on targeted protein degraders. These are orally available small molecule compounds. Many in biopharma are excited about them because they have a clever design that allows them to go after targets that have previously been out of...
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2
Dec
2021

The Variant on the Move

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22
Nov
2021

Reviving Targeted Radiopharmaceuticals for Cancer: Ken Song on The Long Run

Today’s guest on The Long Run is Ken Song. Ken is the CEO of San Diego-based RayzeBio. At RayzeBio, Ken discovered new opportunity in an area cancer R&D that had been long ago abandoned. It’s about creating targeted cancer therapies loaded with radioactive isotopes to give them extra tumor-killing punch. These aren’t the same thing as antibody-drug conjugates, in which...
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