19
Apr
2023
The “D” Word: Delivery is the Next Frontier for Genetic Medicines
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13
Apr
2023
The FDA’s Hour of Need, Digital Tx Pioneer Shuts Down, & HSBC Hires SVB Vets
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13
Apr
2023
Aer Therapeutics Gets $36M Series A to Break Down Mucus in Lungs
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12
Apr
2023
The Frontier of Epigenetic Editing: Chroma CEO Catherine Stehman-Breen
Today’s guest on The Long Run is Catherine Stehman-Breen. Catherine is the CEO of Boston-based Chroma Medicine. Chroma is working on therapies that control gene expression through epigenetic editing. People have heard a lot about editing of the genome with CRISPR, and then subsequent refinements of the technology known as base editing and prime editing. The question at Chroma is... Read More
12
Apr
2023
Function Gets $28M to Make Personalized Cancer Genomics to the Next Level
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10
Apr
2023
In Support of FDA’s Authority to Regulate Medicines
On Friday, April 7, a federal judge with no scientific training fundamentally undermined the bipartisan authority granted by Congress to the Food and Drug Administration to approve and regulate safe, effective medicines for every American. District Judge Matthew Kacsmaryk issued a decision that overturns the FDA’s 23-year-old approval of mifepristone, the primary medicine used in abortion and miscarriage care, and... Read More
8
Apr
2023
Tech, Pharma, and the Uneven Distribution of the AI-Enabled Future
The worlds of technology and entrepreneurship are captivated by recent advances in generative AI and large language models (LLMs). The arrival of ChatGPT, developed by OpenAI (a startup partnered with Microsoft), caused Google to declare a “Code Red,” akin to “pulling the fire alarm,” the New York Times explained. The latest class of startups at Y Combinator are reportedly flocking... Read More
6
Apr
2023
CRISPR, Vertex Seek FDA Milestone, Canaan Pulls in $850M, & Cutting Out the Middleman
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4
Apr
2023
Translating CRISPR Gene-Editing into a Groundbreaking Cell Therapy
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2
Apr
2023
New Book Contemplates How Generative AI Will Serve Man
In 1935, Astounding Science — the premier science fiction magazine of the day, and perhaps ever — published “Proxima Centauri.” It was a short story envisioning an encounter between a voyaging earth spacecraft and a ship from a nearby star system. Written by Murray Leinster (William Fitzgerald Jenkins), the tale features the original use of the phrase “first contact” in... Read More
30
Mar
2023
Jan Skvarka, former Trillium CEO, on Driving a Turnaround
Jan Skvarka isn’t a household name in biotech. Maybe he should be. Skvarka was previously the CEO of Trillium Therapeutics, where he led a remarkable turnaround of the Canadian small cap biotech into a leading immune oncology player. Trillium had a market capitalization of $16 million when he started. Over the next two years, he led it to a $2.26... Read More
29
Mar
2023
Timmerman Traverse for Life Science Cares is Back
The next biotech team adventure is here. I’m thrilled to announce the Timmerman Traverse for Life Science Cares 2023. We’re on a mission to raise $1 million. We’re giving it all back to the most vulnerable people in the communities where we live and work. This trip involves shared sacrifice. We will cover 20+ miles and gain 8,000 feet of... Read More
28
Mar
2023
Treating a Common, Underappreciated Disease: Eric Dobmeier on The Long Run
Today’s guest on The Long Run is Eric Dobmeier. Eric is the CEO of Seattle-based Chinook Therapeutics. Chinook is seeking to develop drugs for kidney diseases. About 10 percent of people on Earth are estimated to have some degree of chronic kidney disease. It ranges from mild forms all the way through end-stage renal disease that requires dialysis. America spends... Read More
23
Mar
2023
Welcome to the AI Irruption
Biopharma, like the rest of the world, appears to be on the threshold of profound, technology-induced change. Incredible advances in artificial intelligence, manifested most recently in GPT-4, are here. This technology, Ezra Klein explains in the New York Times, “changes everything.” Bill Gates describes it as “the most important advance in technology since the graphical user interface,” and declares, “the... Read More
22
Mar
2023
Flare Therapeutics Gets $123M to Make Drugs Against Elusive Transcription Factors
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18
Mar
2023
Takeda Oral Tyk2 Inhibitor, Acquired in Nimbus Deal, Raises the Bar on Psoriasis
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16
Mar
2023
Pfizer Acquires Seagen, Sanofi & Novo Cut Insulin Prices, & Illumina’s Proxy Fight
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16
Mar
2023
The Last Mile of Hepatitis C Treatment
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15
Mar
2023
Big Pharma, VCs Bet $105M on Mediar’s Antibodies for Fibrotic Diseases
Please subscribe and tell your friends why it’s worthwhile. Quality journalism costs money. When you subscribe to Timmerman Report at $199 per year, you reward quality independent biotech reporting, and encourage more. Subscribe Now Sign in to your account.
14
Mar
2023
The Future of Neuroscience Drug R&D: Ryan Watts on The Long Run
Today’s guest on The Long Run is Ryan Watts. Ryan is the co-founder and CEO of South San Francisco-based Denali Therapeutics. Denali is one of the prominent development-stage biotech companies working on treatments for neurodegenerative diseases. It has a pipeline with seven drug candidates in clinical development. It’s developing small molecules and large molecules against a range of neurodegenerative diseases... Read More