15
May
2021
Learning From Post-It: Your Solution Is Not My Problem – Except When It is
A frequent – and frequently correct – critique of entrepreneurs bearing technology is “your solution is not my problem.” Healthcare – among many other domains, perhaps all domains – has been beset by “solutionism,” the idea that my clever technology will solve your hideously complex problem. But perhaps it makes no more sense to instinctively reject this mindset as it... Read More
13
May
2021
Pfizer Advances to Adolescents, Xontogeny’s New Fund & Rekindling Curiosity
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12
May
2021
Aducanumab & the Alzheimer’s Moonshot: What Would It Be Worth to Keep Your Mind?
Have you ever met someone with Alzheimer’s disease? Odds are you probably have. Odds are that question calls to mind the face of a beloved grandparent, neighbor, or family friend whom you’ve stopped by to visit, nervously clenching a bouquet of flowers. You greet them hopefully and wonder if they’ll remember you this time. America’s population is aging. About 6.2... Read More
11
May
2021
Appia Bio Seeks Off-the-Shelf Cancer Therapy With Rare iNKT Cells
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6
May
2021
Biden Threatens Patents, Vaccines Shine, & Biogen’s Pricing Predicament
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6
May
2021
Motivating Fitness With Immersive Experience, Rather Than Competition
Many of us first experience exercise as kids playing sports. Think back to the coach yelling at you and your teammates to run the extra lap. Maybe this helps explain why fitness and competition seem inextricably linked to so many adults, so many years later. Digital fitness companies know this. Many digital fitness offerings lean heavily into the competitive aspect,... Read More
5
May
2021
Startup Profiles: Perlmutter Bets on Super Microscopy; Foresite’s Precision Immunology
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4
May
2021
Spotting Trends and Starting Edgy Companies: Daphne Zohar on The Long Run
Today’s guest on The Long Run is Daphne Zohar. Daphne is the founder and CEO of Boston-based Puretech Health. Puretech has been around since 2005, seeking to capitalize on some of the big trends in biotech. It started out seeking to test concepts from academic labs that could be the basis for new biotech companies – what’s now commonly called... Read More
3
May
2021
RT-PCR Tests for COVID-19 Have Quantitative Power. Let’s Start Using It
Over the past 16 months, 192 billion COVID tests have been carried out globally. A majority are real-time polymerase chain reaction tests (RTqPCR) tests. Every one of those has been reported to patients as an either/or result: positive or, more usually, negative. These tests are capable of doing much, much more than just giving a simple yes/no answer. The “q”... Read More
3
May
2021
Single Cell Analysis Comes of Age, Lighting the Way for Precision Therapies
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29
Apr
2021
J&J Back After Pause, Sanofi Aids Moderna, and a Flood of Women Join Biotech Boards
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29
Apr
2021
AbbVie Bets $90M on Capsida Approach to AAV Gene Therapy
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28
Apr
2021
Rare Side Effects of Adenovirus Vaccines Call for Careful Surveillance
Clinical trials have given us a wealth of information about the effectiveness, and safety profile, of vaccines for COVID-19. But the work of gathering evidence, and weighing the results in the context of an ongoing pandemic, isn’t done. The importance of developing population-based effectiveness and safety profiles associated with a mass vaccination campaign — the sort of deep datasets that... Read More
28
Apr
2021
Boundless Bio, Pushing Frontiers with ecDNA Cancer Therapy, Raises $105M
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27
Apr
2021
Quantified Self Redux?
The first iteration of the “Quantified Self” movement largely fizzled out about five years ago. Avid self-trackers, at the time, started to worry they were drowning in data, but lacking in insight. Today, we seem to be entering Quantified Self 2.0. Once again, an expanding assortment of consumer devices promises to measure every parameter of our health and well-being. The... Read More
27
Apr
2021
Building Momentum and Leverage: How Pandion Ended Up Acquired by Merck
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26
Apr
2021
Liberating Founders and Investors From Narrative Bias
We’re drawn to stories. We understand the world through stories – both the narratives we read, and those we create and develop for ourselves. It’s the very power – the unreasonable effectiveness? – of stories that also leaves us so vulnerable to deception, including self-deception. This is a key message from “Super Founders,” Ali Tamaseb’s soon-to-be-published analysis of the factors... Read More
21
Apr
2021
Versant Ventures, Sticking With its Knitting, Raises $950M for Early Stage Biotechs
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19
Apr
2021
Partnering in a World of Scientific Abundance: James Sabry on The Long Run
Today’s guest on The Long Run is James Sabry. James is the Global Head of Pharma Partnering for Roche. He’s based in Basel, Switzerland. He did his PhD in neuroscience at UCSF, and spent the bulk of his career in biotech in California. After leading a couple of startups, he joined Genentech in 2010 as vice president of partnering. It... Read More
15
Apr
2021
Diversity in Clinical Trials is in Everyone’s Interest
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