4
Dec
2023
Join Me and a Terrific Lineup for ‘Bridging the Gap’ Jan. 23 in Cambridge, Mass.
I’m excited to announce “Bridging the Gap.” It’s an event for the biotech innovation community Jan. 23 in Cambridge, Mass. An outstanding group of speakers is coming together to support a new generation of scientists through the Damon Runyon Cancer Research Foundation. Time: Noon-7 pm Date: Jan. 23 Place: The Engine. 750 Main St., Cambridge, Mass. Tickets are limited. Buy... Read More
30
Nov
2023
ImmunoGen’s Payday, FDA Jolts CAR-T Field, & Another Dupixent Win
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29
Nov
2023
The Final Frontier of Brain Science: Nancy Stagliano on The Long Run
Today’s guest on The Long Run is Nancy Stagliano. She’s the CEO of South San Francisco-based Neuron23. The company is privately held and was started in late 2018. The idea, like we’ve seen in oncology, is to develop targeted therapies for molecularly-defined subgroups of patients with Parkinson’s, Alzheimer’s, and other common neurodegenerative diseases. Nancy is a neuroscientist by training. She... Read More
21
Nov
2023
Nimble Pharmas and Plodding Biotechs: Responses to the IRA Have Flipped the Script
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19
Nov
2023
Industry Insights: Five Key Figures From The Atlas Annual Review
I’ve always been captivated by and drawn to the intersection of raw emerging science, ambitious determined talent, aggressive capital, and savvy strategy that come together in an often-combustible mix to generate novel therapeutics. At the earliest stage, it’s critical to figure out what you’re going to aim at (the molecular target) and what type of therapeutic you’re going to use... Read More
16
Nov
2023
UK Clears 1st CRISPR Drug, Lilly’s siRNA for CV Disease & Blackstone’s Anti-Clotting Win
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13
Nov
2023
Leading the Fight Against Infectious Disease: Diana Brainard on The Long Run
Today’s guest is Diana Brainard. She’s the CEO of Waltham, Mass.-based AlloVir. AlloVir is developing off-the-shelf T cell therapies to fight common viruses. The company is developing these T cells, from donors, and modifying them so they can be given to patients with weakened immune systems. The company’s lead T-cell therapy candidate is made to fight six common viruses, including... Read More
9
Nov
2023
Obesity Drug Rivalry Intensifies, Takeda’s Big FDA Week, & Vor Takes on AML
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9
Nov
2023
Vor Bio Shows CRISPR’d Stem Cell Transplants Take Hold in AML Patients, Enable ADCs
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8
Nov
2023
Architects and Gardeners, a Captivating Developmental Biology Book, & an Inspiring Immigrant Story
Architects and Gardeners Most leadership offsites I’ve attended have included some flavor of personality assessment – not so much to formally classify us, but rather to make the point that different people have different styles, and to emphasize that you can’t assume everyone you work with approaches the world the same way you do. In this spirit, I wanted to... Read More
7
Nov
2023
Kynexis Gets €57M to Pursue New Treatment Pathway for Schizophrenia
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6
Nov
2023
Think Clinical Trials Are Working OK? Ask a Cancer Patient
I can’t stop thinking about a recent series of poignant blog posts, written by an emergency room physician affiliated with the Mayo Clinic. Her husband has been battling a terrible cancer – recurrent/metastatic head and neck squamous cell carcinoma. Given what she does for a living, the author, Dr. Bess Stillman, is about as well-positioned to be a savvy patient... Read More
3
Nov
2023
ProfoundBio, Challenging ImmunoGen, Delivers Responses in First Clinical Trial
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2
Nov
2023
Lilly Doubles Down on Base Editing, BioMarin CEO Exits, and Layoffs Mount
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1
Nov
2023
Investing in the Future of Medicine: Reid Huber on The Long Run
Today’s guest on the The Long Run is Reid Huber. He’s a partner at Third Rock Ventures in Boston. Third Rock is known in biotech as one of the venture firms that creates new companies that seek to turn groundbreaking science into new medicines. Since its founding in 2007, Third Rock has put together a portfolio of 62 companies that... Read More
1
Nov
2023
Gate Bioscience, Backed by Versant, A16Z, Arch, Gets $60M to Block Protein Secretion
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31
Oct
2023
Nimbus HPK1 Inhibitor Activates Immune System Against Tumors in Early Clinical Trial
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28
Oct
2023
How The Unmet Needs of Patients Made Me A (Grounded) BioTechno-Optimist
My Ground Truth Every other week, I stroll across the Longfellow Bridge from Cambridge to Boston. It can be a magnificent walk in the fall and spring, when the weather is temperate and the skies clear. You can see the deep blue of the Charles River, the Esplanade on your left, with the Boston skyline behind it, and the Citgo... Read More
26
Oct
2023
Merck’s ADC Wager, Roche Enters TL1A Rivalry, & OrbiMed Signals Time to Buy
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24
Oct
2023
Aiolos Bio, With $245M from Atlas, Bain, Aims at TSLP for Asthma
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