28
Mar
2019
Postmortem: 5 Lessons Learned from a Public Benefit Rare Disease Startup
On February 26, 2014 the first biotech public benefit corporation was born: Perlstein Lab PBC, which would eventually be renamed Perlara PBC. Almost exactly five years later, this bold and necessary — and some might say overly ambitious — experiment in rare disease drug discovery has ended. For now. Perlara, a company I founded that went on to raise $9.7...Read More 
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26
Mar
2019
Life of a Scientific Entrepreneur: Bob Langer of MIT on The Long Run
Bob Langer is today’s guest on The Long Run. Langer, an Institute Professor at MIT, is one of the nation’s most accomplished scientists and scientific entrepreneurs. Much of his work has focused over the years on tissue engineering and drug delivery systems. It would take half this show to list all of Bob’s contributions to biotechnology, so I won’t. But...Read More
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25
Mar
2019
Researchers Look to the Immune System After Relentless Alzheimer’s Failures
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22
Mar
2019
Sage’s Depression Triumph, Biogen’s Alzheimer’s Defeat, & Apple Watch Hype
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18
Mar
2019
AI Drug Discovery Starts to Come of Age, as it Aims for the Clinic
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14
Mar
2019
Sharpless in the Saddle, NIH Threatened Again, & PBMs Prep for Senate Scrutiny
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12
Mar
2019
Seeing Lots of Single Cells, Up Close: Serge Saxonov of 10X Genomics on The Long Run
Serge Saxonov is today’s guest on The Long Run. Serge is the co-founder and CEO of Pleasanton, California based 10X Genomics. This privately held company, in a nutshell, is a fast-growing supplier for the genomics revolution. 10X, for those unfamiliar, makes instruments, chemical reagents for running experiments, and software that helps scientists collect and analyze various types of data. The...Read More
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7
Mar
2019
Gottlieb Exits, Biogen’s Big Gene Therapy Buy, and Lilly’s Pre-Emptive Price Cut
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6
Mar
2019
Beam Therapeutics, Pushing The Edges in Base Editing, Raises $135M
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5
Mar
2019
The Biotech Industry Can Help Address the Opioid Crisis. But We Aren’t Doing Enough
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1
Mar
2019
Pharma Dodges Senate Bullet, Roche Pays $4.8B for Spark, & BMS-Celgene Deal Wobbles
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28
Feb
2019
Third Rock, Arch Join at Hip, Lead $191M Bet on Maze and ‘Gene Modifiers’
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27
Feb
2019
Staying Resilient, Finding a Way Forward: Julia Owens on The Long Run
Julia Owens is today’s guest on The Long Run. Owens is the CEO of Ann Arbor, Michigan-based Millendo Therapeutics. This company develops drugs for rare endocrine disorders. Prader-Willi syndrome, a terrible genetic disorder that causes young people to develop voracious appetites and which leads to severe obesity, is the focus of the company’s lead drug candidate. It’s entering a pivotal...Read More
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20
Feb
2019
The Boston Cancer Summit and SF Cancer Summit. See the Agenda & Get Your Tickets
The Boston Cancer Summit is loaded with a stellar lineup of speakers on Apr. 16. Same deal with the San Francisco Cancer Summit on Apr. 18. I’m excited to announce the agendas for these special idea-and-networking forums. Hal Barron of GSK, David Schenkein of GV, Cindy Perettie of Foundation Medicine, and Ira Mellman of Genentech are a few of the...Read More
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15
Feb
2019
The PCSK9 Price Cut, J&J Depression Drug Passes Test, & Gilead’s NASH Strikeout
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12
Feb
2019
The Immune Sequencing Frontier (Take 2): Harlan and Chad Robins on The Long Run
Today’s guests on The Long Run are Harlan and Chad Robins. They are brothers and co-founders of Seattle-based Adaptive Biotechnologies. Chad is the CEO, and Harlan is the head of innovation. Harlan is also a faculty member at the Fred Hutchinson Cancer Research Center just down the street from Adaptive. Senior people in pharma R&D are quite familiar with Adaptive....Read More
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8
Feb
2019
Azar Angles for a Deal Pharma Can Live With, Macrogenics’ Big Break, & Sanofi Scraps 38 R&D Programs
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7
Feb
2019
Meet the Kilimanjaro Climb to Fight Cancer Team
The Kilimanjaro Climb to Fight Cancer team is ready to go. We have a full group of 28 biotech executives and investors – 14 women and 14 men – committed to climbing the highest peak in Africa this July. Working together, we’re raising $1 million for cancer research at Fred Hutch. With five months to go, we are about one-fourth...Read More
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6
Feb
2019
Get Tickets Now: The Cancer Summit Series is Coming to Boston, SF, Seattle
We live in a time of tremendous possibility for cancer R&D. Checkpoint inhibitors, cell therapies, molecular diagnostics that catch cancer early and can guide effective custom treatment – these fields are brimming with progress. All were considered speculative at best a decade ago. The science has never been more promising. Yet pricing and access to this new world of cancer...Read More
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30
Jan
2019
Finding a Way in Genomic Diagnostics: Bonnie Anderson of Veracyte on The Long Run
Bonnie Anderson is today’s guest on The Long Run. Bonnie is the CEO of Veracyte. It’s a genomic diagnostics company in South San Francisco. The company markets a line of tests for thyroid cancer, lung cancer, and idiopathic pulmonary fibrosis. Veracyte got started in 2008. Bonnie, as co-founder and CEO, was recruited by Kleiner Perkins Caufield & Byers and a...Read More
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