By

Luke Timmerman

26
Oct
2020

Machine Learning for Drug Discovery: Daphne Koller on The Long Run

Today’s guest on The Long Run is Daphne Koller. Daphne is the CEO of South San Francisco-based insitro. The company is seeking to develop a new platform for drug discovery that leans on a combination of wet labs and machine learning algorithms to spot new biological targets for drug discovery. Artificial intelligence and machine learning have been stirring imaginations in...
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22
Oct
2020

Remdesivir’s FDA Approval, Moderna Fully Enrolls & FDA Wrestles With Trust

Catch up on the main events of the week in biotech with Frontpoints. The FDA issued a surprising approval – not another watered-down Emergency Use Authorization – to Gilead Sciences for remdesivir (Veklury) its antiviral against COVID-19. The antiviral, designed to stop the SARS-CoV-2 virus from copying itself, is now the first treatment fully approved by the FDA against this...
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28
Sep
2020

Small Molecules Against RNA Targets: Jennifer Petter on The Long Run

Today’s guest on The Long Run is Jennifer Petter. She is the founder and chief scientific officer of Waltham, Massachusetts-based Arrakis Therapeutics. Jennifer is a medicinal chemist who has spent her career thinking about how to make small molecules with all the classic Lipinski “Rule of 5” characteristics against protein targets. Five years ago, when she was looking for a...
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17
Sep
2020

A Tribute to Bill Sr.

Before diving into a big week in biotech, let’s pause to think about the life of a tremendous human being we can learn from. RIP Bill Gates Sr. died at age 94. He had Alzheimer’s. The father of one of the world’s richest men was a prominent lawyer, and deeply engaged civic-minded figure in my hometown of Seattle. The older...
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10
Sep
2020

Industry and Academia Take a Stand for Science

Science is under attack. The FDA and the CDC have seen their credibility tarnished, largely because of the relentless pressure, and lies, of certain political leaders. The pharmaceutical industry, built on a bedrock of science, knows darn well that the whole business will come crumbling down if the world continues indulging in this bottomless cynicism and nihilism that says everything...
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8
Sep
2020

Becoming a Biotech VC: Otello Stampacchia on The Long Run

Today’s guest on The Long Run is Otello Stampacchia. He’s the founder and managing director of Omega Funds. Otello started Omega in 2004, and it’s now on Fund VI. Based in Boston, Omega has $1 billion under management, and invests in a wide variety of biotech companies – early stage, later stage, American, European, oncology, immunology, rare disease. There’s a...
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11
Aug
2020

From Rio to Rome: Rosana Kapeller on The Long Run

Today’s guest on The Long Run is Rosana Kapeller. She’s the president and CEO of Cambridge, Mass.-based ROME Therapeutics. ROME aims to discover and develop drugs based on emerging science in what is sometimes called the “repeatome.” These are long repeat stretches of DNA that scientists until recently knew very little about, and still have a lot to learn about...
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