15
Oct
2020
J&J Vaccine Study Paused, Lilly Antibody Paused, and Regeneron’s Ebola FDA Approval
It’s hard to tell yet whether the J&J vaccine and Eli Lilly antibody trials are suffering from momentary blips, or something more serious on the safety front. The AstraZeneca vaccine trial has been stuck on pause in the US since September, which seems like a rather lengthy delay in pandemic terms. Let’s hope they all get back in the saddle... Read More
14
Oct
2020
RayzeBio Snags $45M to Reimagine Targeted Radiotherapies for Cancer
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12
Oct
2020
Looking at Cancer From a Different Angle: Pearl Huang on The Long Run
Today’s guest on The Long Run is Pearl Huang. Pearl is the CEO of Cambridge, Mass.-based Cygnal Therapeutics. Cygnal is a startup dedicated to developing cancer drugs based on some fairly new understanding of the Peripheral Nervous System. For years, scientists assumed that the PNS was merely a conduit of the central nervous system. But what if the PNS is... Read More
8
Oct
2020
A Historic Nobel for CRISPR, Pfizer Sticks Up for FDA, & a CDC Legend Speaks
What a time to be alive in biomedicine. Catch up on the main events in Frontpoints. The Babe Ruth of Public Health Speaks Out William Foege is in his mid-80s. There’s a genome sciences building at the University of Washington named after him because Bill Gates gave money to build it, and he wanted it named after a scientific hero.... Read More
1
Oct
2020
FDA Commissioners Speak Out, An Antibiotic Incentive Proposal and a Drug Price Grilling
Rummaging around in the garage can be about more than just tossing out junk. Going through old files lately, I found a printout from the Carnegie-Knight Task Force in 1997. That was the year I graduated from college and went to work as a local newspaper reporter. The task force, convened by the Project for Excellence in Journalism, was wrestling... Read More
28
Sep
2020
Small Molecules Against RNA Targets: Jennifer Petter on The Long Run
Today’s guest on The Long Run is Jennifer Petter. She is the founder and chief scientific officer of Waltham, Massachusetts-based Arrakis Therapeutics. Jennifer is a medicinal chemist who has spent her career thinking about how to make small molecules with all the classic Lipinski “Rule of 5” characteristics against protein targets. Five years ago, when she was looking for a... Read More
24
Sep
2020
Illumina’s Bet on Early Cancer Detection & ESMO Highlights
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22
Sep
2020
Designing ‘Hyperstable Minibinders’ Against SARS-CoV-2: Q&A With David Baker
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17
Sep
2020
A Tribute to Bill Sr.
Before diving into a big week in biotech, let’s pause to think about the life of a tremendous human being we can learn from. RIP Bill Gates Sr. died at age 94. He had Alzheimer’s. The father of one of the world’s richest men was a prominent lawyer, and deeply engaged civic-minded figure in my hometown of Seattle. The older... Read More
10
Sep
2020
Industry and Academia Take a Stand for Science
Science is under attack. The FDA and the CDC have seen their credibility tarnished, largely because of the relentless pressure, and lies, of certain political leaders. The pharmaceutical industry, built on a bedrock of science, knows darn well that the whole business will come crumbling down if the world continues indulging in this bottomless cynicism and nihilism that says everything... Read More
9
Sep
2020
Recursion Pulls In $239M for AI Drug Discovery, Bayer Bets on Fibrosis
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8
Sep
2020
Becoming a Biotech VC: Otello Stampacchia on The Long Run
Today’s guest on The Long Run is Otello Stampacchia. He’s the founder and managing director of Omega Funds. Otello started Omega in 2004, and it’s now on Fund VI. Based in Boston, Omega has $1 billion under management, and invests in a wide variety of biotech companies – early stage, later stage, American, European, oncology, immunology, rare disease. There’s a... Read More
3
Sep
2020
FDA and CDC Credibility Tarnished; Pfizer Sprints Ahead With COVID19 Vaccine
Credibility takes years to build. It can crumble in seconds. Repairs can take a lifetime. The FDA and the CDC are two of the American public health agencies that became global models of excellence after World War II. We should remember that, and perhaps the FDA and CDC should plaster it up on their walls as a reminder. Both agencies... Read More
20
Aug
2020
Spiritual Renewal in the North Cascades, and Facing Homelessness
All of us need some time and space for spiritual renewal. Especially in a year like 2020. Mountain climbing does it for me. Last weekend, I was fortunate to get out to Mt. Shuksan in the remote North Cascades of Washington. It was a gorgeous climb, led by my friends and partners at Alpine Ascents International. The climb was a... Read More
13
Aug
2020
A Microbiome Turnaround, Novavax Gears Up, & Moderna Commits to 100m Doses
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11
Aug
2020
From Rio to Rome: Rosana Kapeller on The Long Run
Today’s guest on The Long Run is Rosana Kapeller. She’s the president and CEO of Cambridge, Mass.-based ROME Therapeutics. ROME aims to discover and develop drugs based on emerging science in what is sometimes called the “repeatome.” These are long repeat stretches of DNA that scientists until recently knew very little about, and still have a lot to learn about... Read More
6
Aug
2020
GSK’s BCMA Antibody Gets OK, Biogen Teams With Denali & A Telemedicine Megadeal
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23
Jul
2020
Pfizer Secures $2B for COVID-19 Vaccine, BioNTech Raises $500M, & Our Test
When Donald Trump first considered a run for president in 2000, he never rose above 1 percent in the polls. America changed in the early years of the 21st century. Trump was always good at harnessing tabloid media weaknesses to his advantage. When our information commons shifted to a 24/7 advertising-based attention-grab economy on the Internet and TV, he was... Read More
21
Jul
2020
The Road Less Traveled in Biotech: Abe Ceesay on The Long Run
Today’s guest on The Long Run is Abe Ceesay. He’s the CEO of Cambridge, Mass.-based Tiburio Therapeutics. The company is developing a couple of drug candidates for rare neuroendocrine tumors. It raised $31 million in a Series A financing in January 2019 from NEA, Lundbeckford Ventures, Longitude Capital, and Alexandria Real Estate Equities. Abe is in his early 40s, and... Read More
16
Jul
2020
Standing With Fauci, Positive Moderna Vaccine Data, and Blueprint’s Megadeal
Last week in these pages, I wrote a full-throated defense of Tony Fauci. A few days later, the White House sadly started doing what it so often does. It embarked on a dirty tricks smear campaign against someone who speaks inconvenient truth to the public. Peter Navarro, who doesn’t know what he’s talking about when it comes to public health... Read More