28
Mar
2018

Teaching and Mentoring the Next Generation: Vicki Sato on The Long Run Podcast

Today’s guest on The Long Run podcast is Vicki Sato. She’s one of the biotech industry’s pioneers.

Sato started out as a classic academic scientist on the Harvard faculty. Beginning in the mid-1980s, and for about 20 years, the next phase of her career was as an executive at Biogen and Vertex Pharmaceuticals. Her fingerprints are all over a number of drugs that are linchpins for those companies today.

Vicki Sato

The last decade or so she’s been a teacher and mentor — on the Harvard Business School faculty and as a board member. As a director of Bristol-Myers Squibb, Denali Therapeutics and Vir Biotechnology, she oversees strategic direction of companies working on treatments for cancer, neurodegenerative disease, and infectious disease. Having been around for this many years, she’s wise. And tough. But she’s also a warm person who cares a lot about the next generation of biotech leaders. She splits her time now between Boston and New York. Fun fact: She says she’s enjoying the culture of the Big City and dances the tango – competitively.

It was a treat to sit down with her and discuss her career arc.  

Before diving in, a word of thanks to the sponsors of the show: Presage Biosciences and Harvard Medical School executive education.

Next on The Long Run: Chad and Harlan Robins, the co-founders and brothers who run Seattle-based Adaptive Biotechnologies. This company has raised about $400 million over the years, and carved out a niche in immune sequencing, or immune profiling — a novel application of next-gen sequencing technology. We talked some about the science, the business strategy, and what it’s like to manage a company as brothers.

Now, join me and Vicki Sato for The Long Run.

26
Mar
2018

Mt. Everest: It’s Time

Six months of hard training is in the bank. Tomorrow morning, I will lug a pair of 120-liter gear bags to the airport and get on the plane for Kathmandu.

Destination: Mt. Everest, 29,029 feet/8,848 meters. The summit of the highest mountain in the world.

No matter what happens, three things are certain: I’ve given it everything I’ve got to prepare physically and mentally. I’m in good hands with the guides at Alpine Ascents International. And I’m eternally grateful for all of your support for the Everest Climb to Fight Cancer campaign at Fred Hutch.

The fundraising total for cancer research stands at $329,110.

Thank you, thank you, thank you.

What can you expect between now and when I get home to the U.S. on June 2?

  1. Six episodes of The Long Run podcast. They will air on schedule every two weeks through June 6. Vicki Sato is the guest on the next show. Watch for that one Mar. 28.
  2. Smart industry coverage. TR contributing writers Kyle Serikawa and Timothy Hay, formerly of The Wall Street Journal, will publish pieces.
  3. A pause on business correspondence. When on the mountain, I will be focused on the mountain. If you need to reach me about anything business-related, we’ll talk in June.
  4. Team updates from the mountain. Many of you want to know how to follow the expedition. I will not be blogging, tweeting or podcasting from Base Camp (see Everest FAQs). But expedition leader Ben Jones of Alpine Ascents International will narrate regular updates – in text and via satellite phone audio. Here’s the link to bookmark: https://www.alpineascents.com/climbs/mount-everest/cybercasts/
  5. Afterward, photos from the top of the world. I made sure my point-and-shoot digital zoom camera can be operated with bulky mittens. I will be carrying a notebook and pen (rated for -30 Fahrenheit temperatures). I’ll be thinking about articles, slideshows or talks that may come after the climb.

For more background on the Climb to Fight Cancer and the Everest expedition, check the links below.

http://engage.fredhutch.org/site/PageServer?pagename=2011climb_greeting

https://timmermanreport.com/everest-fundraiser-for-cancer-research/

Thank you to the folks at Fred Hutch, and a few special guests, for making this send-off video. I’ve really enjoyed working with you on this.

Keep pursuing your great adventures in biotech. — Luke

12
Mar
2018

Photo Gallery: The Boston Cancer Summit

What a whirlwind last week was! The Seattle and Boston Cancer Summits were an East-West combo punch on behalf of the Everest Climb to Fight Cancer fundraising campaign for Fred Hutch.

These events did the job: Bringing together leading thinkers and doers on both coasts, they both drew sellout, highly engaged crowds. The fundraising tally now stands at $326,000!!

The weather forecast for a nor’easter in Boston made me a little nervous, but the snow didn’t interfere. Everything came off without a hitch. Both of these gatherings were brimming with ideas, positive energy toward tackling the challenges of cancer R&D, good humor, and well wishes about my upcoming summit bid on the world’s highest mountain.

Special thanks to the sponsors of this campaign that began in October:

Summit: Sanofi

South Col: 10X Genomics

Advanced Base Camp:

Alexandria Real Estate Equities

Takeda Pharmaceuticals

Khumbu Icefall: Novateur

Base Camp:

Sofinnova Ventures

5AM Ventures

ARCH Venture Partners

Alnylam Pharmaceuticals

EBD Group

Loncar Investments

Photo credit for the Boston Cancer Summit: David Parnes.

I also want to thank the great team of people who did so much work behind the scenes to make these events happen. At Fred Hutch in Seattle, that includes Cate Tambeaux, Kristin Nash, Kelly O’Brien, and Niki Robinson. At Sanofi Genzyme in Cambridge, special thanks go to Ashleigh Koss, Anna Robinson, and Christy Maginn.

Two from now, on Mar. 27, I will get on the plane for Nepal, and won’t be coming back from Everest until June 2. You can read FAQs about the expedition and donate to the campaign here if you haven’t already.

I’m feeling great physically, and privileged to be in position to do this climb and bring so much fundraising and attention to this moment of possibility in cancer research. Thanks to you being part of it.

Enjoy the photos!

BOSTON CANCER SUMMIT: MAR. 7, 2018

12
Mar
2018

Photo Gallery: The Seattle Cancer Summit

What a whirlwind last week was! The Seattle and Boston Cancer Summits were an East-West combo punch on behalf of the Everest Climb to Fight Cancer fundraising campaign for Fred Hutch.

These events did the job: Bringing together leading thinkers and doers on both coasts, they both drew sellout, highly engaged crowds. The fundraising tally now stands at $326,000!!

The weather forecast for a nor’easter in Boston made me a little nervous, but the snow didn’t interfere. Everything came off without a hitch. Both of these gatherings were brimming with ideas, positive energy toward tackling the challenges of cancer R&D, good humor, and well wishes about my upcoming summit bid on the world’s highest mountain.

Special thanks to the sponsors of this campaign that began in October:

Summit: Sanofi

South Col: 10X Genomics

Advanced Base Camp:

Alexandria Real Estate Equities

Takeda Pharmaceuticals

Khumbu Icefall: Novateur

Base Camp:

Sofinnova Ventures

5AM Ventures

ARCH Venture Partners

Alnylam Pharmaceuticals

EBD Group

Loncar Investments

Photo credits from the Seattle Cancer Summit were by Josh Belzman. Boston Cancer Summit photos were by David Parnes (see those in a separate post).

I also want to thank the great team of people who did so much work behind the scenes to make these events happen. At Fred Hutch in Seattle, that includes Cate Tambeaux, Kristin Nash, Kelly O’Brien, and Niki Robinson. At Sanofi Genzyme in Cambridge, special thanks go to Ashleigh Koss, Anna Robinson, and Christy Maginn.

Two from now, on Mar. 27, I will get on the plane for Nepal, and won’t be coming back from Everest until June 2. You can read FAQs about the expedition and donate to the campaign here if you haven’t already.

I’m feeling great physically, and privileged to be in position to do this climb and bring so much fundraising and attention to this moment of possibility in cancer research. Thanks to you being part of it.

SEATTLE CANCER SUMMIT: MAR.5, 2018

 

16
Feb
2018

All-Star Lineup for Boston Cancer Summit, March 7: Novartis, J&J, Third Rock, Atlas

Timmerman Report is bringing together major East Coast cancer R&D players for an intimate half-day event on March 7: the Boston Cancer Summit. Join an all-star gathering of pharma executives, hot startups, and VCs making things happen in the treatment and diagnosis of cancer. 

Tickets are sold out. The conference will be at Sanofi Genzyme’s flagship building in the heart of Kendall Square. All proceeds go to a good cause: basic cancer research at the Fred Hutchinson Cancer Research Center, as part of my Everest Climb to Fight Cancer fundraising campaign.

We’ll talk about aiming for elusive cancer targets, where VCs see opportunities for investment, cancer diagnostics in the DNA information age, designing clinical trials for fast answers, and emerging modalities for cancer care. You’ll also see more than a few entrepreneurs who I consider to be newsmakers of tomorrow.

PROGRAM

1 pm. Registration and Networking.

1:30 pm Welcome Remarks. Luke Timmerman, founder of Timmerman Report. Kelly O’ Brien, VP of Philanthropy, Fred Hutchinson Cancer Research Center. Gary Nabel, Chief Scientific Officer and Senior Vice President of Sanofi. 

1:40 pm

Emerging company presentations

A series of five brief, 10-minute presentations from exciting East Coast drug developers working to fight cancer in their own way. They are:

  • Barbara Weber, CEO, Tango Therapeutics (synthetic lethal cancer drugs)
  • Garry Menzel, CEO, TCR2 Therapeutics (T cell therapies aimed at solid tumors)
  • Nancy Simonian, CEO, Syros Pharmaceuticals (targeted drugs for gene expression)
  • Hugh O’Dowd, CEO, Neon Therapeutics (neoantigen therapeutics)
  • David Meeker, CEO, KSQ Therapeutics (CRISPRomics cancer drug discovery)

2:40 pm

Cancer investment overfloweth. Where do forward-looking VCs see opportunity?

Kush Parmar, managing partner, 5AM Ventures

  • John Evans, venture partner at ARCH Venture Partners
  • Kush Parmar, managing partner at 5AM Ventures
  • Alexis Borisy, partner at Third Rock Ventures
  • Moderator: Michael Gilman, CEO of Obsidian Therapeutics

3:10 pm

Cancer diagnostics in the DNA information age: Getting validated and rewarded via FDA/CMS parallel review

  • Melanie Nallicheri, chief business officer of Foundation Medicine
  • Kevin Conroy, CEO of Exact Sciences
  • Moderator: Luke Timmerman

3:40 pm

Designing clinical trials for clear, fast (not too expensive) answers when the scientific sands are constantly shifting underneath your feet

  • Jo Lager, VP, head of development at Sanofi Oncology
  • Beth Trehu, chief medical officer of Jounce Therapeutic 
  • Moderator: Luke Timmerman

4:10 pm

Closing chat: New modalities for cancer care

Jay Bradner, president, Novartis Institutes for Biomedical Research

  • Jay Bradner, president of the Novartis Institutes for Biomedical Research
  • Robert Urban, global head of J&J Innovation
  • Moderator: Bruce Booth, partner at Atlas Venture

4:30 pm

Cocktail hour + the Everest Climb to Fight Cancer

Before the cocktail hour, I might have a couple minutes for a fun surprise to give you a taste of the Everest climb.


When & Where

TIME: 12:30 p.m. to 6 p.m.

DATE: March 7

PLACE: Sanofi Genzyme, 500 Kendall St., Cambridge, MA

TICKETS:

At the Door: $350


Sponsors: Thank you

Summit Sponsor:

  • Sanofi

South Col Sponsor:

  • 10X Genomics

Advanced Base Camp Sponsors:

  • Takeda Pharmaceuticals
  • Alexandria Real Estate Equities

Khumbu Icefall Sponsor:

  • Novateur

Base Camp Sponsors:

  • 5AM Ventures
  • Sofinnova Ventures
  • Arch Venture Partners
  • EBD Group
  • Alnylam Pharmaceuticals
  • Loncar Investments