10
Jan
2020
Entering JPM20 With a Grounded, Yet Hopeful, View of Health Tech
Health tech seems balanced precariously between excessive optimism and excessive skepticism, between the promise that emerging technology is poised to disrupt health like it has so many other areas, and the painful recognition that many idealistic technologists misunderstood both the scientific and human dimensions of the inordinately complex problems to be solved in both health care services and the development... Read More
9
Jan
2020
MRNA Vaccines Impress, Blueprint Wins First FDA OK, & Calif. Gov. Stares Down Biotech on the Eve of #JPM20
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9
Jan
2020
Sanofi’s New CEO Captures Pharma’s Grounded View of Health Tech
Since taking over as Sanofi’s CEO in September, Paul Hudson has been blunt in his assessment of health technology decisions, and indecisions, made by previous management. Early in his tenure, Hudson took square aim at his company’s once-heralded $500 million collaboration with Verily on Onduo. This partnership was started in 2016 and intended to help diabetics better manage their condition. ... Read More
7
Jan
2020
We’ve Been Neglecting Common Diseases. We Need to Reverse this Trend
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6
Jan
2020
Three Lessons for Business Ahead of JPM, from the Kilimanjaro Climb to Fight Cancer
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2
Jan
2020
HBV Curative Treatments Gear Up in the Clinic, as HCV Combos Help to Guide the Way
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1
Jan
2020
New Job, Same Thesis: Aligning Tech & Pharma To Elicit Best Of Both
With the New Year, I’m very excited to share a professional update: as of January 1, I’m the proud founder of “Astounding HealthTech,” providing advisory services to R&D-driven biopharma organizations and health tech startups striving to engage each other more effectively. The mission of Astounding is to catalyze drug development by aligning the specific capabilities and distinct needs of individual... Read More
30
Dec
2019
Designer Proteins as Better Therapies: David Baker on The Long Run
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26
Dec
2019
Losing 80 Lbs Was Hard; Keeping It Off Was So Much Harder
Last year, at about this time, I shared my experience losing 80 pounds. I achieved this goal through a low-carb diet and coaching, guided by the Virta program, along with regular exercise. The overarching concern I expressed in that article, one year ago, was my recognition of how fragile weight loss can be. Most people who lose significant weight soon gain it... Read More
10
Dec
2019
Biotechs Build on Single-cell Analytics for Drug R&D, as Human Cell Atlas is Mapped
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5
Dec
2019
Aural Pleasures, 2019 Edition
I listen to a lot of audio, spoken word content that edifies (or at least distracts) me during daily workouts and when traveling. Traditionally in December, I like to share with readers my annual podcast recommendations. But in reflecting on my listening habits of the last year, I realized that I’ve probably spent at least as much time listening to... Read More
3
Dec
2019
Sticking With Epigenetics During Lean Times: Jigar Raythatha on The Long Run
Today’s guest on The Long Run is Jigar Raythatha. Jigar is the CEO of Cambridge, Mass.-based Constellation Pharmaceuticals. This company is built to develop drugs against epigenetic targets. Simply put, this is a way to turn genes on or off without altering the underlying DNA. The pharmaceutical industry fancied this idea about a decade ago, as a way to shut... Read More
2
Dec
2019
IFM, Staying Small, Raises (Merely) $55.5M, Promotes Former Novartis Exec to CEO
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26
Nov
2019
Tamping Down Inflammation & Synaptic Dysfunction in Alzheimer’s: John Alam on The Long Run
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21
Nov
2019
AI Can Help with Repeatable Processes, But Don’t Expect Thunderbolts for Drug Discovery
Biopharmaceutical and healthcare executives increasingly find themselves attending conferences and presentations featuring the evangelistic selling of AI by self-assured VCs, energetic entrepreneurs, and earnest consultants. The promise is that AI will change everything. Then the executives return to work, face the quotidian reality of their operation, and wonder whether AI will change anything. Enter Jim Manzi. Manzi, depending on your view, is a... Read More
19
Nov
2019
Running the KRAS Marathon with Wellspring, and Visualizing a Second-Half Kick
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18
Nov
2019
Feeding Frenzy: The Ecosystem is Growing Stronger
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14
Nov
2019
Merck’s Ebola Vaccine Triumph, Weill’s $106M Neurohub & Teva’s Reversal
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12
Nov
2019
Scientist, Entrepreneur, Rock Collector: Tim Springer on The Long Run
Today’s guest on The Long Run is Tim Springer. Tim wears many hats. First and foremost, he’s a scientist. An immunologist to be specific, at Harvard Medical School. He’s best known for his discovery of integrins, a class of transmembrane receptors. Now in his early 70s, Tim recently won the Gairdner Award, sometimes called the Canadian Nobel. The prize committee... Read More
12
Nov
2019
Don’t Pull Back on Basic Biology for Psychiatry: It’s Time to Double Down
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