17
Apr
2020
Getting it Right: Walking the Diagnostic and Serologic Testing Tightrope
Last week I felt like I was coming down with something. My throat hurt and I had a bit of a dry cough. A dreadful feeling set in. Obviously, I had COVID-19. My mother and her partner, both in their 70s, are currently living with me in Seattle. My friend’s son had recently returned from New York. A few days... Read More
17
Apr
2020
Hunting for Antibodies Against COVID19: George Scangos on The Long Run
Today’s guest on The Long Run is George Scangos. George is the CEO of San Francisco-based VIR Biotechnology. VIR has been all over the news the past couple months. It’s at the forefront of companies racing to discover and develop broadly neutralizing antibodies against the SARS-CoV-2 virus that’s sparked a global pandemic. VIR was founded in early 2017 by some... Read More
17
Apr
2020
Bridging the Social Divide in the Pandemic
Halfway through an explanation to a patient I am treating for a suspected case of COVID-19, I realize I don’t know the Spanish term for “sanitizing wipes.” I’m in my new clinical home base, where Massachusetts General Hospital has cordoned off special care for COVID-19 patients. There are modular plastic walls and bright fluorescent lights. A few weeks ago, this... Read More
16
Apr
2020
Serology Testing: Keep an Eye Out for Quick-and-Dirty Tests
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16
Apr
2020
Scaling Up Biotech Drugs and Vaccines Against COVID19 Won’t Be Easy
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15
Apr
2020
Don’t Waste this Crisis: Solving the Patient Cost-Share Problem
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15
Apr
2020
Drug Repurposing to Keep COVID19 Patients Out of the ICU
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14
Apr
2020
A Healthcare Investor, and Doctor, Peering into the Fog
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14
Apr
2020
Why COVID-19 Can’t Be Directly Compared With the Flu
A few years ago, I was preparing for a live radio interview about prostate cancer screening, my main area of research for the past 20 years. As a statistician focused on getting the numbers right, I disagreed strongly with the new national recommendation from an influential task force that guides practice and reimbursement. Members of that task force argued against... Read More
14
Apr
2020
The Pandemic Takes A Certain Kind of Toll on African Americans
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9
Apr
2020
GSK Partners With Vir on Antibodies, Pfizer With BioNTech on Vaccines, & the Testing Fiasco Continues
Here we are heading into Easter Weekend. We’re the wealthiest country in the world, and the undisputed superpower of biomedicine. Yet we’re still playing a game of catch up against SARS-CoV-2, which apparently our intelligence community knew was emerging around Thanksgiving. Even after months to get our act together, we still don’t have a coordinated national strategy on exactly how... Read More
8
Apr
2020
Facing the Consequences of a Misinformation Pandemic
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7
Apr
2020
George Yancopoulos, That Rarest Of Species – A Physician-Scientist Still In Charge Of A Pharma
Growing up in an academic household (my parents are both professors at Yale Medical School, still engaged, as ever, in dyslexia research), it was perhaps inevitable that, outside of my parents, my first role model was the brilliant President of Yale University, the late Bart Giamatti (you know- Paul’s dad). The elder Giamatti inspired me so much as a teenager... Read More
7
Apr
2020
Rationale for Testing Anticoagulants Against COVID19
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7
Apr
2020
COVID-19 Models: What Makes Them Tick?
As the COVID-19 pandemic unfolds, questions about its likely course are much on our minds. How long will it last? How bad will it get? And are we doing enough to flatten the curve? These questions are not about the past, but about the future. Models are now frequently cited in public by elected leaders to inform expectations and justify... Read More
6
Apr
2020
I’ve Got a Fund Full of Toilet Paper and I’m Ready to Deal!
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6
Apr
2020
Where the Puck is Going: Serologic Testing for SARS-CoV-2 Immunity
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6
Apr
2020
Loss and Grief in the Time of Covid-19
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4
Apr
2020
Diagnostic Dysfunction for COVID19: Mike Pellini on The Long Run
Today’s guest on The Long Run is Mike Pellini. Mike is a managing partner with Section32, a venture firm that invests in biotech startups. Mike is an expert in diagnostics. He was previously the CEO of Foundation Medicine, a company that looks at a wide range of gene mutations in tumor samples to can act as molecular drivers of cancer.... Read More
2
Apr
2020
A Baffling Coronavirus Response, Arch & Flagship Reload, & Merck Passes 2 Phase IIIs
The world now has more than 1 million confirmed cases of infection with an insidious virus that spreads from person to person with exponential speed, is spread by people who don’t display symptoms, and kills an estimated 1 percent of people who get infected. As the US death toll now exceeds more than 1,000 a day from COVID-19, we are... Read More